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Last updated: 2016/10/16
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MC1R polyclonal antibody

  • Catalog # : PAB25002
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of MC1R.
  • Immunogen:
  • A synthetic peptide corresponding to MC1R.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 35
  • Reactivity:
  • Human
  • Specificity:
  • MC1R polyclonal antibody detects endogenous levels of MC1R.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    Immunofluorescence (1:50-1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of COLO 205 cell extracts with MC1R polyclonal antibody (Cat # PAB25002).
  • Immunofluorescence
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 4157
  • Gene Name:
  • MC1R
  • Gene Alias:
  • MGC14337,MSH-R,SHEP2
  • Gene Description:
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
  • Gene Summary:
  • This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq
  • Other Designations:
  • melanocortin 1 receptor,melanocyte stimulating hormone receptor,melanotropin receptor
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