CYP2D6 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of HT-29 cell extracts with CYP2D6 polyclonal antibody (Cat # PAB24990).
Immunohistochemistry
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney carcinoma tissue at 1:50, showing endoplasmic reticulum membrane staining. Negative control (the right) using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-Biotin followed by avidin-peroxidase.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYP2D6.
Immunogen
A synthetic peptide corresponding to amino acids 241-290 of human CYP2D6.
Host
Rabbit
Theoretical MW (kDa)
55
Reactivity
Human
Specificity
CYP2D6 polyclonal antibody detects endogenous levels of CYP2D6 protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Purity
>95% (by SDS-PAGE)
Recommend Usage
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HT-29 cell extracts with CYP2D6 polyclonal antibody (Cat # PAB24990).Immunohistochemistry
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney carcinoma tissue at 1:50, showing endoplasmic reticulum membrane staining. Negative control (the right) using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-Biotin followed by avidin-peroxidase. -
Gene Info — CYP2D6
Entrez GeneID
1565Protein Accession#
P10635Gene Name
CYP2D6
Gene Alias
CPD6, CYP2D, CYP2D@, CYP2DL1, MGC120389, MGC120390, P450-DB1, P450C2D, P450DB1
Gene Description
cytochrome P450, family 2, subfamily D, polypeptide 6
Omim ID
124030Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
cytochrome P450 2D6|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1|debrisoquine 4-hydroxylase|flavoprotein-linked monooxygen
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