DNMT3B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DNMT3B.
Immunogen
A synthetic peptide corresponding to DNMT3B.
Host
Rabbit
Theoretical MW (kDa)
96
Reactivity
Human
Specificity
DNMT3B polyclonal antibody detects endogenous levels of DNMT3B protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HT-29 cell lysate with DNMT3B polyclonal antibody (Cat # PAB24969).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using DNMT3B polyclonal antibody (Cat # PAB24969).Immunofluorescence
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Gene Info — DNMT3B
Entrez GeneID
1789Gene Name
DNMT3B
Gene Alias
ICF, M.HsaIIIB
Gene Description
DNA (cytosine-5-)-methyltransferase 3 beta
Gene Ontology
HyperlinkGene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq
Other Designations
DNA MTase HsaIIIB|DNA cytosine-5 methyltransferase 3 beta|DNA methyltransferase HsaIIIB
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