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Last updated: 2017/7/16

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BARD1 polyclonal antibody

  • Catalog # : PAB24949
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of BARD1.
  • Immunogen:
  • A synthetic peptide corresponding to BARD1.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • ~85.0
  • Reactivity:
  • Human
  • Specificity:
  • BARD1 polyclonal antibody detects endogenous levels of BARD1 protein.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    Immunohistochemistry (1:50-1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of HeLa cell lysate with BARD1 polyclonal antibody (Cat # PAB24949) at 1:500 dilution.
  • Immunohistochemistry
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry
  • Gene Information
  • Entrez GeneID:
  • 580
  • Gene Name:
  • BARD1
  • Gene Alias:
  • -
  • Gene Description:
  • BRCA1 associated RING domain 1
  • Gene Summary:
  • This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq
  • Other Designations:
  • BRCA1-associated RING domain 1,BRCA1-associated RING domain gene 1
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