BARD1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate with BARD1 polyclonal antibody (Cat # PAB24949) at 1:500 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BARD1.
Immunogen
A synthetic peptide corresponding to BARD1.
Host
Rabbit
Theoretical MW (kDa)
~85.0
Reactivity
Human
Specificity
BARD1 polyclonal antibody detects endogenous levels of BARD1 protein.
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate with BARD1 polyclonal antibody (Cat # PAB24949) at 1:500 dilution.Immunohistochemistry
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Gene Info — BARD1
Entrez GeneID
580Gene Name
BARD1
Gene Alias
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Gene Description
BRCA1 associated RING domain 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq
Other Designations
BRCA1-associated RING domain 1|BRCA1-associated RING domain gene 1
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Interactome
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Disease
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