CRH polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CRH.
Immunogen
A synthetic peptide corresponding to CRH.
Host
Rabbit
Reactivity
Human
Specificity
CRH polyclonal antibody detects endogenous levels of CRH.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human lung carcinoma tissue with CRH polyclonal antibody (Cat # PAB24940). -
Gene Info — CRH
Entrez GeneID
1392Gene Name
CRH
Gene Alias
CRF
Gene Description
corticotropin releasing hormone
Gene Ontology
HyperlinkGene Summary
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition. [provided by RefSeq
Other Designations
corticotropin-releasing factor
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Interactome
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Disease
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