CD247 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of CD247 (arrow) using rabbit CD247 polyclonal antibody (Cat # PAB2494). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CD247 gene (Lane 2) (Origene Technologies).
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CD247.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CD247.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Transfected lysate)
Western blot analysis of CD247 (arrow) using rabbit CD247 polyclonal antibody (Cat # PAB2494). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CD247 gene (Lane 2) (Origene Technologies). -
Gene Info — CD247
Entrez GeneID
919Protein Accession#
NP_932170;P20963Gene Name
CD247
Gene Alias
CD3-ZETA, CD3H, CD3Q, CD3Z, T3Z, TCRZ
Gene Description
CD247 molecule
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD247 antigen, zeta subunit|CD3Z antigen, zeta polypeptide (TiT3 complex)|OTTHUMP00000032544|T-cell antigen receptor complex, zeta subunit of CD3|T-cell receptor T3 zeta chain|T-cell receptor zeta chain|T-cell surface glycoprotein CD3 zeta chain
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T.
Rheumatology (Oxford, England) 2008 Feb; 47(2):158.
-
Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls.
Gorman CL, Russell AI, Zhang Z, Cunninghame Graham D, Cope AP, Vyse TJ.
Journal of Immunology 2008 Jan; 180(2):1060.
Application：Flow Cyt, Human, Human lymphocytes.
-
Chronic inflammation and T cell zeta-chain downregulation in hemodialysis patients.
Eleftheriadis T, Kartsios C, Yiannaki E, Kazila P, Antoniadi G, Liakopoulos V, Markala D.
American Journal of Nephrology 2008 Oct; 28(1):152.
Application：Flow Cyt, Human, T cells from hemodialysis (HD) patients.
-
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com