Western blot analysis of CD247 (arrow) using rabbit CD247 polyclonal antibody (Cat # PAB2494). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CD247 gene (Lane 2) (Origene Technologies).
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq