Products

Western Blot (Cell lysate)

Immunohistochemistry

Entrez GeneID

Gene Name

NR1I3

Gene Alias

CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209

Gene Description

nuclear receptor subfamily 1, group I, member 3

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000032245|OTTHUMP00000032246|constitutive activator of retinoid response|constitutive active receptor|constitutive androstane receptor|orphan nuclear hormone receptor