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Last updated: 2016/11/27

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DMPK polyclonal antibody

  • Catalog # : PAB24919
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of DMPK.
  • Immunogen:
  • A synthetic peptide corresponding to DMPK.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 70
  • Reactivity:
  • Human
  • Specificity:
  • DMPK polyclonal antibody detects endogenous levels of DMPK protein.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of Jurkat cell lysate with DMPK polyclonal antibody (Cat # PAB24919).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1760
  • Gene Name:
  • DMPK
  • Gene Alias:
  • DM,DM1,DM1PK,DMK,MDPK,MT-PK
  • Gene Description:
  • dystrophia myotonica-protein kinase
  • Gene Summary:
  • The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq
  • Other Designations:
  • DM protein kinase,dystrophia myotonica 1,myotonic dystrophy associated protein kinase,myotonic dystrophy protein kinase,myotonin protein kinase A,thymopoietin homolog
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