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Last updated: 2017/5/28
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CYP2C8/CYP2C9/CYP2C18/CYP2C19 polyclonal antibody

  • Catalog # : PAB24906
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of CYP2C8/CYP2C9/CYP2C18/CYP2C19.
  • Immunogen:
  • A synthetic peptide corresponding to CYP2C8/CYP2C9/CYP2C18/CYP2C19.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 60
  • Reactivity:
  • Human
  • Specificity:
  • CYP2C8/CYP2C9/CYP2C18/CYP2C19 polyclonal antibody detects endogenous levels of CYP2C8/CYP2C9/CYP2C18/CYP2C19 protein.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    Immunohistochemistry (1:50-1:200)
    Immunofluorescence (1:50-1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of LoVo cell lysate with CYP2C8/CYP2C9/CYP2C18/CYP2C19 polyclonal antibody (Cat # PAB24906).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using CYP2C8/CYP2C9/CYP2C18/CYP2C19 polyclonal antibody (Cat # PAB24906).
  • Immunofluorescence
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 1558
  • Gene Name:
  • CYP2C8
  • Gene Alias:
  • CPC8,MP-12/MP-20
  • Gene Description:
  • cytochrome P450, family 2, subfamily C, polypeptide 8
  • Gene Summary:
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000020134,P450 form 1,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8,flavoprotein-linked monooxygenase,microsomal monooxygenase,s-mephenytoin 4-hydroxylase,xenobiotic monooxygenase
  • Gene Information
  • Entrez GeneID:
  • 1559
  • Gene Name:
  • CYP2C9
  • Gene Alias:
  • CPC9,CYP2C,CYP2C10,MGC149605,MGC88320,P450IIC9
  • Gene Description:
  • cytochrome P450, family 2, subfamily C, polypeptide 9
  • Gene Summary:
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000020135,cytochrome P-450 S-mephenytoin 4-hydroxylase,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9,cytochrome p4502C9,flavoprotein-linked mon
  • Gene Information
  • Entrez GeneID:
  • 1562
  • Gene Name:
  • CYP2C18
  • Gene Alias:
  • CPCI,CYP2C,CYP2C17,DKFZp686I24235,P450-6B/29C,P450IIC17
  • Gene Description:
  • cytochrome P450, family 2, subfamily C, polypeptide 18
  • Gene Summary:
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • (S)-mephenytoin hydroxylase associated cytochrome P450,OTTHUMP00000020131,cytochrome P450 family 2 subfamily C polypeptide 18,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxyl
  • Gene Information
  • Entrez GeneID:
  • 1557
  • Gene Name:
  • CYP2C19
  • Gene Alias:
  • CPCJ,CYP2C,P450C2C,P450IIC19
  • Gene Description:
  • cytochrome P450, family 2, subfamily C, polypeptide 19
  • Gene Summary:
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000020132,OTTHUMP00000059588,S-mephenytoin 4-hydroxylase,cytochrome P-450 II C,cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19,flavoprotein-linked monooxygenase,mephenytoin 4'-hydroxylase,microsomal monooxygenase,xenobi
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