TNFSF9 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HUVEC cell lysate with TNFSF9 polyclonal antibody (Cat # PAB24880).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNFSF9.
Immunogen
A synthetic peptide corresponding to TNFSF9.
Host
Rabbit
Theoretical MW (kDa)
23
Reactivity
Human
Specificity
TNFSF9 polyclonal antibody detects endogenous levels of TNFSF9 protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Purity
> 95% by SDS-PAGE
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 1x PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HUVEC cell lysate with TNFSF9 polyclonal antibody (Cat # PAB24880).Immunofluorescence
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Gene Info — TNFSF9
Entrez GeneID
8744Gene Name
TNFSF9
Gene Alias
4-1BB-L, CD137L
Gene Description
tumor necrosis factor (ligand) superfamily, member 9
Omim ID
606182Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction
Other Designations
homolog of mouse 4-1BB-L|receptor 4-1BB ligand
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Interactome
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