XRCC3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of XRCC3.
Immunogen
A synthetic peptide corresponding to XRCC3.
Host
Rabbit
Theoretical MW (kDa)
38
Reactivity
Human
Specificity
XRCC3 polyclonal antibody detects endogenous levels of XRCC3 protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Purity
> 95% by SDS-PAGE
Recommend Usage
Western Blot (1:500-1000)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 1x PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of 293 cell lysate (treated with serum 10% 15min) with XRCC3 polyclonal antibody (Cat # PAB24835).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using XRCC3 polyclonal antibody (Cat # PAB24835). -
Gene Info — XRCC3
Entrez GeneID
7517Gene Name
XRCC3
Gene Alias
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Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 3
Omim ID
600675Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq
Other Designations
DNA repair protein XRCC3|RAD51-like|X-ray repair cross complementing protein 3|X-ray-repair, complementing defective, repair in Chinese hamster
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Interactome
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Pathway
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Disease
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Publication Reference
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RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.
Michael A Longo, Sunetra Roy, Yue Chen, Karl-Heinz Tomaszowski, Andrew S Arvai, Jordan T Pepper, Rebecca A Boisvert, Selvi Kunnimalaiyaan, Caezanne Keshvani, David Schild, Albino Bacolla, Gareth J Williams, John A Tainer, Katharina Schlacher.
Nature Communications 2023 Jul; 14(1):4445.
Application:PLA, Human, HAP1 cell.
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RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.
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