IAPP polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IAPP.
Immunogen
A synthetic peptide corresponding to IAPP.
Host
Rabbit
Theoretical MW (kDa)
25
Reactivity
Human
Specificity
IAPP polyclonal antibody detects endogenous levels of IAPP protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Purity
> 95% by SDS-PAGE
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 1x PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate (treated with EGF 200ng/ml 30min) with IAPP polyclonal antibody (Cat # PAB24819).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using IAPP polyclonal antibody (Cat # PAB24819).Immunofluorescence
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Gene Info — IAPP
Entrez GeneID
3375Gene Name
IAPP
Gene Alias
AMYLIN, DAP, IAP
Gene Description
islet amyloid polypeptide
Omim ID
147940Gene Ontology
HyperlinkGene Summary
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq
Other Designations
Islet amyloid polypeptide (diabetes-associated peptide; amylin)
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Interactome
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Pathway
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Disease
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