GATA4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GATA4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GATA4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of GATA4 polyclonal antibody (Cat # PAB2480) in CEM cell line lysates (35 ug/lane). GATA4 (arrow) was detected using the purified polyclonal antibody.Western Blot (Transfected lysate)
Western blot analysis of GATA4 (arrow) using rabbit GATA4 polyclonal antibody (Cat # PAB2480). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GATA4 gene (Lane 2) (Origene Technologies). -
Gene Info — GATA4
Entrez GeneID
2626Protein Accession#
NP_002043;P43694Gene Name
GATA4
Gene Alias
MGC126629
Gene Description
GATA binding protein 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq
Other Designations
GATA-binding protein 4|OTTHUMP00000116010
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Interactome
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Disease
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Publication Reference
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Spectrum of heart disease associated with murine and human GATA4 mutation.
Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT.
Journal of Molecular and Cellular Cardiology 2007 Dec; 43(6):677.
Application:WB-Ti, Mouse , Mouse hearts.
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Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles.
Philips AS, Kwok JC, Chong BH.
The Journal of Biological Chemistry 2007 Jun; 282(34):2491.
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Spectrum of heart disease associated with murine and human GATA4 mutation.
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