CDH8 polyclonal antibody
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More Files
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Western Blot (Transfected lysate)
Western blot analysis of CDH8 (arrow) using rabbit CDH8 polyclonal antibody (Cat # PAB2476). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH8 gene (Lane 2) (Origene Technologies).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinomareacted with CDH8 polyclonal antibody (Cat # PAB2476), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDH8.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CDH8.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of CDH8 (arrow) using rabbit CDH8 polyclonal antibody (Cat # PAB2476). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH8 gene (Lane 2) (Origene Technologies).Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinomareacted with CDH8 polyclonal antibody (Cat # PAB2476), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — CDH8
Entrez GeneID
1006Protein Accession#
NP_001787;P55286Gene Name
CDH8
Gene Alias
Nbla04261
Gene Description
cadherin 8, type 2
Omim ID
603008Gene Ontology
HyperlinkGene Summary
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq
Other Designations
cadherin-8|putative protein product of Nbla04261
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Interactome
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Disease
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Publication Reference
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Expression of cadherin-8 in renal cell carcinoma and fetal kidney.
Blaschke S, Mueller CA, Markovic-Lipkovski J, Puch S, Miosge N, Becker V, Mueller GA, Klein G.
International Journal of Cancer 2002 Oct; 101(4):327.
Application：IHC-P, IF, Human, MB, GL cells, Renal.
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Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M.
The Biochemical Journal 2000 Jul; 349(Pt 1):159.
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Expression of cadherin-8 in renal cell carcinoma and fetal kidney.
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