APOBEC1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot (Cell lysate) analysis of HepG2 whole cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the APOBEC1 polyclonal antibody (Cat # PAB2473) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APOBEC1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human APOBEC1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot (Cell lysate) analysis of HepG2 whole cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the APOBEC1 polyclonal antibody (Cat # PAB2473) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — APOBEC1
Entrez GeneID
339Protein Accession#
NP_001635Gene Name
APOBEC1
Gene Alias
APOBEC-1, BEDP, CDAR1, HEPR
Gene Description
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Omim ID
600130Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. [provided by RefSeq
Other Designations
apolipoprotein B mRNA editing enzyme|apolipoprotein B mRNA editing enzyme complex-1
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Interactome
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Pathway
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Disease
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Publication Reference
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A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.
Blanc V, Kennedy S, Davidson NO.
The Journal of Biological Chemistry 2003 Aug; 278(42):41198.
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The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.
Chester A, Somasekaram A, Tzimina M, Jarmuz A, Gisbourne J, O'Keefe R, Scott J, Navaratnam N.
The EMBO Journal 2003 Aug; 22(15):3971.
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Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.
Wedekind JE, Dance GS, Sowden MP, Smith HC.
Trends in Genetics 2003 Apr; 19(4):207.
Application：WB-Tr, Human, Cancers, Mammalian cells.
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A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.
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