APOBEC3G polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The APOBEC3G polyclonal antibody (Cat # PAB2472) is used in Western blot to detect APOBEC3G in A-375 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the APOBEC3G polyclonal antibody (Cat # PAB2472) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APOBEC3G.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of humanAPOBEC3G.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The APOBEC3G polyclonal antibody (Cat # PAB2472) is used in Western blot to detect APOBEC3G in A-375 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the APOBEC3G polyclonal antibody (Cat # PAB2472) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — APOBEC3G
Entrez GeneID
60489Protein Accession#
AAG14956Gene Name
APOBEC3G
Gene Alias
ARP9, CEM15, FLJ12740, MDS019, bK150C2.7, dJ494G10.1
Gene Description
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
Omim ID
607113Gene Ontology
HyperlinkGene Summary
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq
Other Designations
DNA dC->dU editing enzyme|OTTHUMP00000028911|phorbolin-like protein MDS019
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Interactome
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Pathway
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Disease
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Publication Reference
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The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.
Kao S, Khan MA, Miyagi E, Plishka R, Buckler-White A, Strebel K.
Journal of Virology 2003 Nov; 77(21):11398.
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HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.
Stopak K, de Noronha C, Yonemoto W, Greene WC.
Molecular Cell 2003 Sep; 12(3):591.
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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.
Mangeat B, Turelli P, Caron G, Friedli M, Perrin L, Trono D.
Nature 2003 Jul; 424(6944):99.
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The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity.
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