RCAN1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
RCAN1 polyclonal antibody (Cat # PAB24686) (1 ug/ml) staining of mouse brain (lane 2) and KO mouse brain (lane 1) lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RCAN1.
Immunogen
A synthetic peptide corresponding to internal region of human RCAN1.
Sequence
CHIGSSHLAPPNPD
Host
Goat
Theoretical MW (kDa)
40
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5 % BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
RCAN1 polyclonal antibody (Cat # PAB24686) (1 ug/ml) staining of mouse brain (lane 2) and KO mouse brain (lane 1) lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RCAN1
Entrez GeneID
1827Protein Accession#
NP_004405.3;NP_981962.1;NP_981963.1Gene Name
RCAN1
Gene Alias
ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
Gene Description
regulator of calcineurin 1
Omim ID
602917Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Down syndrome candidate region 1|Down syndrome critical region gene 1|calcipressin 1|calcium and oxidant-inducible mRNA|modulatory calcineurin-interacting protein 1|myocyte-enriched calcineurin-interacting protein 1|near DSCR proline-rich protein
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Interactome
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Disease
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