TERT polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TERT.
Immunogen
A synthetic peptide corresponding to amino acids 597-611 at internal region of human TERT.
Sequence
C-QLRELSEAEVRQHRE
Host
Goat
Theoretical MW (kDa)
140
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_937983.2; (NP_001180305.1).
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TERT polyclonal antibody (Cat # PAB24580) (0.5 ug/mL) staining of human skeletal muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TERT
Entrez GeneID
7015Protein Accession#
NP_937983.2;NP_001180305.1Gene Name
TERT
Gene Alias
EST2, TCS1, TP2, TRT, hEST2
Gene Description
telomerase reverse transcriptase
Gene Ontology
HyperlinkGene Summary
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq
Other Designations
telomerase catalytic subunit
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Interactome
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Disease
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