ATP2B1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
ATP2B1 polyclonal antibody (Cat # PAB24566) (0.03 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ATP2B1.
Immunogen
A synthetic peptide corresponding to amino acids 312-327 at internal region of human ATP2B1.
Sequence
C-KQDGAIENRNKAKAQD
Host
Goat
Theoretical MW (kDa)
150
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_001001323.1; NP_001673.2).
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
ELISA (1:64000)
Western Blot (0.03-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
ATP2B1 polyclonal antibody (Cat # PAB24566) (0.03 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ATP2B1
Entrez GeneID
490Protein Accession#
NP_001001323.1;NP_001673.2Gene Name
ATP2B1
Gene Alias
PMCA1, PMCA1kb
Gene Description
ATPase, Ca++ transporting, plasma membrane 1
Omim ID
108731Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
plasma membrane calcium ATPase 1|plasma membrane calcium pump|plasma membrane calcium-ATPase
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Interactome
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Pathway
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Disease
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