BIK polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BIK.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BIK.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The BIK polyclonal antibody (Cat # PAB2449) is used in Western blot to detect BIK in mouse brain tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the BIK polyclonal antibody (Cat # PAB2449) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — BIK
Entrez GeneID
638Protein Accession#
NP_001188;Q13323Gene Name
BIK
Gene Alias
BIP1, BP4, NBK
Gene Description
BCL2-interacting killer (apoptosis-inducing)
Omim ID
603392Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. [provided by RefSeq
Other Designations
BCL2-interacting killer|OTTHUMP00000028974|apoptosis-inducing NBK
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Interactome
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Disease
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Publication Reference
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The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.
Albor A, El-Hizawi S, Horn EJ, Laederich M, Frosk P, Wrogemann K, Kulesz-Martin M.
The Journal of Biological Chemistry 2006 Jun; 281(35):25850.
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The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.
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