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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human breast with ABCB8 polyclonal antibody (Cat # PAB24392) shows moderate cytoplasmic and nuclear positivity in glandular cells.

Immunofluorescence

Immunofluorescent staining of human cell line U-251 MG with ABCB8 polyclonal antibody (Cat # PAB24392) at 1-4 ug/mL dilution shows positivity in nucleus and mitochondria.

Entrez GeneID

11194

Protein Accession#

Q9NUT2

Gene Name

ABCB8

Gene Alias

EST328128, M-ABC1, MABC1

Gene Description

ATP-binding cassette, sub-family B (MDR/TAP), member 8

Omim ID

605464

Gene Ontology

Hyperlink

Gene Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq

Other Designations

ATP-binding cassette, sub-family B, member 8|mitochondrial ABC protein