HM13 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant HM13.
Immunogen
Recombinant protein corresponding to amino acids of human HM13.
Sequence
PASFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSIVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGC
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human pancreas with HM13 polyclonal antibody (Cat # PAB24385) shows strong cytoplasmic positivity in exocrine cells at 1:200-1:500 dilution. -
Gene Info — HM13
Entrez GeneID
81502Protein Accession#
Q8TCT9Gene Name
HM13
Gene Alias
H13, IMP1, IMPAS, MSTP086, PSENL3, PSL3, SPP, dJ324O17.1
Gene Description
histocompatibility (minor) 13
Omim ID
607106Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000030527|OTTHUMP00000030528|intramembrane protease|minor histocompatibility antigen 13|presenilin-like protein 3|signal peptide peptidase beta
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