SUMO2 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SUMO2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SUMO2.
Host
Rabbit
Reactivity
Human
Specificity
BH3 Domain Specific
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The SUMO2 polyclonal antibody (Cat # PAB2435) is used in Western blot to detect SUMO2 in GST-SUMO2 fusion protein (lane 1) and HL-60 cell lysate (lane 2) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the SUMO2 polyclonal antibody (Cat # PAB2435) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — SUMO2
Entrez GeneID
6613Protein Accession#
NP_008868;P61956Gene Name
SUMO2
Gene Alias
HSMT3, MGC117191, SMT3B, SMT3H2
Gene Description
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
Omim ID
603042Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
SMT3 suppressor of mif two 3 homolog 2|sentrin 2|small ubiquitin-like modifier 2, isoform a
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Interactomes
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Publication Reference
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Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies.
Zhang YQ, Sarge KD.
Journal of Cellular Biology 2008 Jul; 182(1):35.
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Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies.
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