SENP2 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of SENP2 polyclonal antibody (Cat # PAB2415) in HL-60 cell lysate. SENP2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the SENP2 polyclonal antibody (Cat # PAB2415) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SENP2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SENP2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SENP2 polyclonal antibody (Cat # PAB2415) in HL-60 cell lysate. SENP2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the SENP2 polyclonal antibody (Cat # PAB2415) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — SENP2
Entrez GeneID
59343Protein Accession#
NP_067640;Q9HC62Gene Name
SENP2
Gene Alias
AXAM2, DKFZp762A2316, KIAA1331, SMT3IP2
Gene Description
SUMO1/sentrin/SMT3 specific peptidase 2
Omim ID
608261Gene Ontology
HyperlinkGene Summary
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM
Other Designations
SUMO1/sentrin/SMT3 specific protease 2|sentrin-specific protease
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Interactome
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Pathway
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Publication Reference
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Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.
Zhang H, Saitoh H, Matunis MJ.
Molecular and Cellular Biology 2002 Sep; 22(18):6498.
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Association of the human SUMO-1 protease SENP2 with the nuclear pore.
Hang J, Dasso M.
The Journal of Biological Chemistry 2002 May; 277(22):19961.
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Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation.
Nishida T, Kaneko F, Kitagawa M, Yasuda H.
The Journal of Biological Chemistry 2001 Oct; 276(42):39060.
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Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.
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