SETD2 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human oral mucosa with SETD2 polyclonal antibody (Cat # PAB23943) shows moderate nuclear positivity in squamous epithelial cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SETD2.
Immunogen
Recombinant protein corresponding to amino acids of human SETD2.
Sequence
NLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVA
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:1000-1:2500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human oral mucosa with SETD2 polyclonal antibody (Cat # PAB23943) shows moderate nuclear positivity in squamous epithelial cells. -
Gene Info — SETD2
Entrez GeneID
29072Protein Accession#
Q9BYW2Gene Name
SETD2
Gene Alias
FLJ16420, FLJ22472, FLJ23184, FLJ45883, FLJ46217, HIF-1, HSPC069, HYPB, KIAA1732, KMT3A, SET2, p231HBP
Gene Description
SET domain containing 2
Gene Ontology
HyperlinkGene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq
Other Designations
SET domain-containing protein 2|histone-lysine N-methyltransferase SETD2|huntingtin interacting protein 1|huntingtin yeast partner B|huntingtin-interacting protein B|lysine N-methyltransferase 3A
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Interactome
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Pathway
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Disease
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