Products

Western Blot (Transfected lysate)

Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate).
Lane 2: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells with TYROBP polyclonal antibody (Cat # PAB23872).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human bone marrow with TYROBP polyclonal antibody (Cat # PAB23872) shows strong cytoplasmic positivity in hematopoietic cells.

Entrez GeneID

7305

Protein Accession#

O43914

Gene Name

TYROBP

Gene Alias

DAP12, KARAP, PLOSL

Gene Description

TYRO protein tyrosine kinase binding protein

Omim ID

221770 604142

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined. [provided by RefSeq

Other Designations

DNAX-activation protein 12|killer activating receptor associated protein