Immunohistochemical staining of human vagina with TSPAN16 polyclonal antibody (Cat # PAB23831) shows strong cytoplasmic, membranous and nuclear positivity in squamous epithelial cells at 1:50-1:200 dilution.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. [provided by RefSeq
tetraspanin TM4-B,transmembrane 4 superfamily member 16