Immunohistochemical staining of human stomach with KATNB1 polyclonal antibody (Cat # PAB23761) shows strong cytoplasmic positivity in glandular cells at 1:1000-1:2500 dilution.
Immunofluorescent staining of human cell line U-2 OS with KATNB1 polyclonal antibody (Cat # PAB23761) at 1-4 ug/mL dilution shows positivity in plasma membrane, cytoplasm and cytoskeleton (microtubules).
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq
katanin (80 kDa),katanin p80 (WD40-containing) subunit B 1,katanin p80 subunit B 1