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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human stomach with ADAMTS10 polyclonal antibody (Cat # PAB23637) shows strong cytoplasmic positivity in glandular cells at 1:10-1:20 dilution.

Entrez GeneID

81794

Protein Accession#

Q9H324

Gene Name

ADAMTS10

Gene Alias

ADAM-TS10, WMS

Gene Description

ADAM metallopeptidase with thrombospondin type 1 motif, 10

Omim ID

277600 608990

Gene Ontology

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Gene Summary

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq

Other Designations

Weill-Marchesani syndrome|a disintegrin and metalloproteinase with thrombospondin motifs 10|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10|a disintegrin-like and metalloprotease domain with thrombospondin typ