SUV39H1 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of SUV39H1 polyclonal antibody (Cat # PAB2362) in SAOS-2 cell lysate (Lane 1) and NIH/3T3 cell lysate (Lane 2) . SUV39H1 (arrow) is detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant SUV39H1.
Immunogen
Recombinant GST fusion protein corresponding to N-terminus of human SUV39H1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SUV39H1 polyclonal antibody (Cat # PAB2362) in SAOS-2 cell lysate (Lane 1) and NIH/3T3 cell lysate (Lane 2) . SUV39H1 (arrow) is detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. -
Gene Info — SUV39H1
Entrez GeneID
6839Protein Accession#
NP_003164Gene Name
SUV39H1
Gene Alias
KMT1A, MG44, SUV39H
Gene Description
suppressor of variegation 3-9 homolog 1 (Drosophila)
Omim ID
300254Gene Ontology
HyperlinkGene Summary
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. [provided by RefSeq
Other Designations
H3-K9-HMTase 1|OTTHUMP00000024298|Su(var)3-9 homolog 1|histone H3-K9 methyltransferase 1|histone-lysine N-methyltransferase, H3 lysine-9 specific 1|suppressor of variegation 3-9 homolog 1
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Interactome
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Pathway
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Publication Reference
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pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.
Macaluso M, Cinti C, Russo G, Russo A, Giordano A.
Oncogene 2003 Jun; 22(23):3511.
Application：WB, Human, MCF-7, MDA-MB-231 cells.
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Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.
Fujita N, Watanabe S, Ichimura T, Tsuruzoe S, Shinkai Y, Tachibana M, Chiba T, Nakao M.
The Journal of Biological Chemistry 2003 Jun; 278(26):24132.
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Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing.
Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G.
The EMBO Journal 2002 Mar; 21(5):1121.
Application：IF, WB, Drosophila, Drosophila embryo, silivary gland.
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pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.
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