Western blot analysis of SUV39H1 polyclonal antibody (Cat # PAB2362) in SAOS-2 cell lysate (Lane 1) and NIH/3T3 cell lysate (Lane 2) . SUV39H1 (arrow) is detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. [provided by RefSeq
H3-K9-HMTase 1,OTTHUMP00000024298,Su(var)3-9 homolog 1,histone H3-K9 methyltransferase 1,histone-lysine N-methyltransferase, H3 lysine-9 specific 1,suppressor of variegation 3-9 homolog 1