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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human stomach with PTPRU polyclonal antibody (Cat # PAB23587) shows strong cytoplasmic positivity in glandular cells at 1:200-1:500 dilution.

Entrez GeneID

10076

Protein Accession#

Q92729

Gene Name

PTPRU

Gene Alias

FLJ37530, FMI, GLEPP1, PCP-2, PTP, PTP-J, PTP-PI, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, hPTP-J

Gene Description

protein tyrosine phosphatase, receptor type, U

Omim ID

602454

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq

Other Designations

OTTHUMP00000003801|OTTHUMP00000003802|Receptor protein tyrosine phosphatase hPTP-J|pi R-PTP-Psi|protein tyrosine phosphatase J|protein tyrosine phosphatase receptor omicron