Immunohistochemical staining of human cerebellum with AP3B2 polyclonal antibody (Cat # PAB23583) shows strong cytoplasmic positivity in purkinje cells.
Immunofluorescent staining of human cell line U-251 MG with AP3B2 polyclonal antibody (Cat # PAB23583) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli, cytoplasm and golgi apparatus.
Adaptor protein-3 (AP3) is a heterotetrameric vesicle-coat protein complex. Some AP3 subunits are ubiquitously expressed, whereas others are expressed exclusively in neurons. The neuron-specific AP3 complex, which includes AP3B2, is thought to serve neuron-specific functions such as neurotransmitter release (Grabner et al., 2006 [PubMed 16788073]).[supplied by OMIM