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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human testis with AKAP3 polyclonal antibody (Cat # PAB23578) shows moderate cytoplasmic positivity in spermatids at 1:500-1:1000 dilution.

Entrez GeneID

10566

Protein Accession#

O75969

Gene Name

AKAP3

Gene Alias

AKAP110, FSP95, PRKA3, SOB1

Gene Description

A kinase (PRKA) anchor protein 3

Omim ID

604689

Gene Ontology

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Gene Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. [provided by RefSeq

Other Designations

A-kinase anchor protein 3|A-kinase anchor protein, 110kDa|Fibrous Sheath Protein of 95 kDa|fibrous sheath protein, 95kDa|fibrousheathin 1|protein kinase A anchoring protein 3|sperm oocyte-binding protein 1