NLRP10 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant NLRP10.
Immunogen
Recombinant protein corresponding to amino acids of human NLRP10.
Sequence
RLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDLEFSLYEAKIKNLVKGIQMNNVSFKIKHSNEKKSQ
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Western Blot (1:250-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells) with NLRP10 polyclonal antibody (Cat # PAB23553) at 1:250-1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human lateral ventricle with NLRP10 polyclonal antibody (Cat # PAB23553) shows strong cytoplasmic positivity in neuronal cells at 1:50-1:200 dilution. -
Gene Info — NLRP10
Entrez GeneID
338322Protein Accession#
Q86W26Gene Name
NLRP10
Gene Alias
CLR11.1, NALP10, NOD8, PAN5, PYNOD
Gene Description
NLR family, pyrin domain containing 10
Omim ID
609662Gene Ontology
HyperlinkGene Summary
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq
Other Designations
NACHT, leucine rich repeat and PYD containing 10|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
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Interactome
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Disease
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