NCOR1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The NCOR1 polyclonal antibody (Cat # PAB2352) is used in Western blot to detect NCOR1 in mouse thymus tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the NCOR1 polyclonal antibody (Cat # PAB2352) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NCOR1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human NCOR1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The NCOR1 polyclonal antibody (Cat # PAB2352) is used in Western blot to detect NCOR1 in mouse thymus tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the NCOR1 polyclonal antibody (Cat # PAB2352) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — NCOR1
Entrez GeneID
9611Protein Accession#
O75376Gene Name
NCOR1
Gene Alias
KIAA1047, MGC104216, N-CoR, TRAC1, hCIT529I10, hN-CoR
Gene Description
nuclear receptor co-repressor 1
Omim ID
600849Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. [provided by RefSeq
Other Designations
thyroid hormone- and retinoic acid receptor-associated corepressor 1
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Interactome
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Disease
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Publication Reference
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CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.
Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW.
Biochemical and Biophysical Research Communications 2003 Aug; 308(1):170.
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The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor.
Ishizuka T, Lazar MA.
Molecular and Cellular Biology 2003 Aug; 23(15):5122.
Application：WB-Tr, Human, HEK 293T cells.
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The nuclear receptor corepressor (N-CoR) modulates basal and activated transcription of genes controlled by retinoic acid.
Loinder K, Soderstrom M.
The Journal of Steroid Biochemistry and Molecular Biology 2003 Jan; 84(1):15.
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CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.
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