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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human placenta with CACNA1H polyclonal antibody (Cat # PAB23513) shows strong cytoplasmic positivity in trophoblastic cells at 1:10-1:20 dilution.

Entrez GeneID

8912

Protein Accession#

O95180

Gene Name

CACNA1H

Gene Alias

CACNA1HB, Cav3.2, EIG6, FLJ90484

Gene Description

calcium channel, voltage-dependent, T type, alpha 1H subunit

Omim ID

607904

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq

Other Designations

calcium channel, voltage-dependent, T type, alpha 1Hb subunit|calcium channel, voltage-dependent, alpha 1H subunit|low-voltage-activated calcium channel alpha1 3.2 subunit|low-voltage-activated calcium channel alpha13.2 subunit|voltage dependent t-type ca