Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human stomach with MADD polyclonal antibody (Cat # PAB23504) shows moderate cytoplasmic and membranous positivity in glandular cells.

Immunofluorescence

Immunofluorescent staining of human cell line U-2 OS with MADD polyclonal antibody (Cat # PAB23504) at 1-4 ug/mL dilution shows positivity in plasma membrane.

Entrez GeneID

8567

Protein Accession#

Q8WXG6

Gene Name

MADD

Gene Alias

DENN, FLJ35600, FLJ36300, IG20, KIAA0358, RAB3GEP

Gene Description

MAP-kinase activating death domain

Omim ID

603584

Gene Ontology

Hyperlink

Gene Summary

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq

Other Designations

MAP-kinase activating death domain-containing protein|Rab3 GDP/GTP exchange factor|differentially expressed in normal and neoplastic cells|insulinoma-glucagonoma protein 20