MYST1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MYST1 polyclonal antibody (Cat # PAB2349) in K-562 cell line lysates (35 ug/lane). MYST1 (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MYST1 polyclonal antibody (Cat # PAB2349) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MYST1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 417-446 at C-terminus of human MYST1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MYST1 polyclonal antibody (Cat # PAB2349) in K-562 cell line lysates (35 ug/lane). MYST1 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MYST1 polyclonal antibody (Cat # PAB2349) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. -
Gene Info — MYST1
Entrez GeneID
84148Protein Accession#
NP_115564;Q9H7Z6Gene Name
MYST1
Gene Alias
FLJ14040, KAT8, MOF, hMOF
Gene Description
MYST histone acetyltransferase 1
Omim ID
609912Gene Ontology
HyperlinkGene Summary
The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin (Neal et al., 2000 [PubMed 10786633]).[supplied by OMIM
Other Designations
histone acetyltransferase MYST1|ortholog of Drosophila males absent on the first (MOF)
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Interactome
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Disease
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Publication Reference
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The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma.
Pfister S, Rea S, Taipale M, Mendrzyk F, Straub B, Ittrich C, Thuerigen O, Sinn HP, Akhtar A, Lichter P.
International Journal of Cancer 2008 Mar; 122(6):1207.
Application：IHC-P, Human, Human breast cancer, medulloblastomas.
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The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.
Gupta A, Guerin-Peyrou TG, Sharma GG, Park C, Agarwal M, Ganju RK, Pandita S, Choi K, Sukumar S, Pandita RK, Ludwig T, Pandita TK.
Molecular and Cellular Biology 2008 Jan; 28(1):397.
Application：WB, Mouse, Human, Mouse fibroblasts.
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Males absent on the first (MOF): from flies to humans.
Rea S, Xouri G, Akhtar A.
Oncogene 2007 Aug; 26(37):5385.
Application：IP, WB, Human, A-T fibroblasts, HEK 293 cells.
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The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma.
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