HDAC11 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of HDAC11 polyclonal antibody (Cat # PAB2342) in mouse brain tissue lysate. HDAC11 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the HDAC11 polyclonal antibody (Cat # PAB2342) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HDAC11.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human HDAC11.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of HDAC11 polyclonal antibody (Cat # PAB2342) in mouse brain tissue lysate. HDAC11 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the HDAC11 polyclonal antibody (Cat # PAB2342) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — HDAC11
Entrez GeneID
79885Protein Accession#
Q96DB2Gene Name
HDAC11
Gene Alias
FLJ22237
Gene Description
histone deacetylase 11
Omim ID
607226Gene Ontology
HyperlinkGene Summary
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants
Other Designations
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Interactome
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Publication Reference
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Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.
Bradbury CA, Khanim FL, Hayden R, Bunce CM, White DA, Drayson MT, Craddock C, Turner BM.
Leukemia 2005 Oct; 19(10):1751.
Application：WB-Ce, Human, HL-60, HeLa cells.
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Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene.
Voelter-Mahlknecht S, Ho AD, Mahlknecht U.
International Journal of Molecular Medicine 2005 Oct; 16(4):589.
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Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.
Gregoretti IV, Lee YM, Goodson HV.
Journal of Molecular Biology 2004 Apr; 338(1):17.
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Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.
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