ATP4A polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human stomach with ATP4A polyclonal antibody (Cat # PAB23402) shows strong cytoplasmic positivity in parietal cells at 1:20-1:50 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ATP4A.
Immunogen
Recombinant protein corresponding to amino acids of human ATP4A.
Sequence
TDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQ
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human stomach with ATP4A polyclonal antibody (Cat # PAB23402) shows strong cytoplasmic positivity in parietal cells at 1:20-1:50 dilution. -
Gene Info — ATP4A
Entrez GeneID
495Protein Accession#
P20648Gene Name
ATP4A
Gene Alias
ATP6A
Gene Description
ATPase, H+/K+ exchanging, alpha polypeptide
Omim ID
137216Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq
Other Designations
ATPase, H+/K+ transporting, alpha polypeptide|OTTHUMP00000045780|gastric H+/K+ ATPase alpha subunit|gastric H,K-ATPase catalytic subunit|gastric hydrogen-potassium ATPase|hydrogen/potassium-exchanging ATPase 4A|potassium-transporting ATPase alpha chain 1|
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Interactome
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Pathway
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Publication Reference
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Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.
Ding C, Scicluna BP, Stroo I, Yang J, Roelofs JJTH, de Boer OJ, de Vos AF, Nürnberg P, Revenko AS, Crosby J, Van't Veer C, van der Poll T.
The Journal of Pathology 2020 Jan; 250(1):95.
Application：WB, Human, Human plasma.
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Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.
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