Immunohistochemical staining of human cerebellum with MAP1A polyclonal antibody (Cat # PAB23390) shows strong cytoplasmic positivity in Purkinje cells, cells in molecular layer and cells in granular layer.
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq
OTTHUMP00000196074,microtubule-associated protein 1-like