SPG20 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant SPG20.
Immunogen
Recombinant protein corresponding to amino acids of human SPG20.
Sequence
AGAYMFPDTMLQAAGCFVGVVLSSELPEDDRELFEDLLRQMSDLRLQANWNRAEEENEFQIPGRTRPSSDQLKEASGTDVKQLDQGNKDVRHKGKRGKRAKDTSSE
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human placenta with SPG20 polyclonal antibody (Cat # PAB23388) shows strong cytoplasmic positivity in trophoblastic cells at 1:200-1:500 dilution. -
Gene Info — SPG20
Entrez GeneID
23111Protein Accession#
Q8N0X7Gene Name
SPG20
Gene Alias
KIAA0610, SPARTIN, TAHCCP1
Gene Description
spastic paraplegia 20 (Troyer syndrome)
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq
Other Designations
OTTHUMP00000018254|spartin|spastic paraplegia 20, spartin (Troyer syndrome)|spastic paraplegia autosomal recessive Troyer syndrome|trans-activated by hepatitis C virus core protein 1
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Interactome
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Disease
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