NSUN2 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human testis with NSUN2 polyclonal antibody (Cat # PAB23182) shows strong nuclear positivity in cells in seminiferus ducts and leydig cells.
Immunofluorescence
Immunofluorescent staining of human cell line A-431 with NSUN2 polyclonal antibody (Cat # PAB23182) at 1-4 ug/mL dilution shows positivity in nucleus.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant NSUN2.
Immunogen
Recombinant protein corresponding to amino acids of human NSUN2.
Sequence
PFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCAFRLAQ
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:500-1:1000)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human testis with NSUN2 polyclonal antibody (Cat # PAB23182) shows strong nuclear positivity in cells in seminiferus ducts and leydig cells.Immunofluorescence
Immunofluorescent staining of human cell line A-431 with NSUN2 polyclonal antibody (Cat # PAB23182) at 1-4 ug/mL dilution shows positivity in nucleus. -
Gene Info — NSUN2
Entrez GeneID
54888Protein Accession#
Q08J23Gene Name
NSUN2
Gene Alias
FLJ20303, MISU, SAKI, TRM4
Gene Description
NOL1/NOP2/Sun domain family, member 2
Omim ID
610916Gene Ontology
HyperlinkGene Summary
Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA) (Brzezicha et al., 2006 [PubMed 17071714]).[supplied by OMIM
Other Designations
5-methycytoisine methyltransferase|Myc-induced SUN-domain-containing protein|NOL1/NOP2/Sun domain family 2|NOL1/NOP2/Sun domain family 2 protein|tRNA methyltransferase 4 homolog
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Interactome
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Disease
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