Products

Western Blot

Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with POLR2B polyclonal antibody (Cat # PAB23123) at 1:250-1:500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human oral mucosa with POLR2B polyclonal antibody (Cat # PAB23123) shows strong nuclear positivity in squamous epithelial cells at 1:500-1:1000 dilution.

Immunofluorescence

Immunofluorescent staining of human cell line A-431 with POLR2B polyclonal antibody (Cat # PAB23123) at 1-4 ug/mL dilution shows positivity in nucleus but not nucleoli.

Entrez GeneID

5431

Protein Accession#

P30876

Gene Name

POLR2B

Gene Alias

POL2RB, RPB2, hRPB140, hsRPB2

Gene Description

polymerase (RNA) II (DNA directed) polypeptide B, 140kDa

Omim ID

180661

Gene Ontology

Hyperlink

Gene Summary

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. [provided by RefSeq

Other Designations

DNA directed RNA polymerase II 140 kDa polypeptide, RNA polymerase II subunit 2, RNA polymerase II second largest subunit|DNA directed RNA polymerase II polypeptide B|OTTHUMP00000158973|polymerase (RNA) II (DNA directed) polypeptide B (140kD)