Western blot analysis of PAK6 polyclonal antibody (Cat # PAB2303) in lysates from transiently transfected COS-7 cells. Lane 1 : negative control. Lane 2 : PAK1-expressing cells. Lane 3 : PAK2-expressing cells Lane 4 : PAK4-expressing cells. Lane 5 : PAK5-expressing cells. Lane 6 : PAK6-expressing cells. PAK6 (arrow) was detected using purified polyclonal antibody. Data is kindly provided by Drs. Z.M. Jaffer and J. Chernoff from the Fox Chase Cancer Center (Philadelphia, PA) .
This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
p21(CDKN1A)-activated kinase 6,p21-activated kinase 6,p21-activated protein kinase 6