DMGDH polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with DMGDH polyclonal antibody (Cat # PAB23001) shows strong granular cytoplasmic positivity in cells in tubules at 1:20-1:50 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant DMGDH.
Immunogen
Recombinant protein corresponding to amino acids of human DMGDH.
Sequence
TLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPAVIIQEPLVLTEPTRNRLQK
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with DMGDH polyclonal antibody (Cat # PAB23001) shows strong granular cytoplasmic positivity in cells in tubules at 1:20-1:50 dilution. -
Gene Info — DMGDH
Entrez GeneID
29958Protein Accession#
Q9UI17Gene Name
DMGDH
Gene Alias
DMGDHD, ME2GLYDH
Gene Description
dimethylglycine dehydrogenase
Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. [provided by RefSeq
Other Designations
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Pathway
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Disease
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