STK24 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STK24.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human STK24.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate (35 ug/lane) with STK24 polyclonal antibody (Cat # PAB2297).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the STK24 polyclonal antibody (Cat # PAB2297) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — STK24
Entrez GeneID
8428Protein Accession#
Q9Y6E0Gene Name
STK24
Gene Alias
MST-3, MST3, MST3B, STE20, STK3
Gene Description
serine/threonine kinase 24 (STE20 homolog, yeast)
Omim ID
604984Gene Ontology
HyperlinkGene Summary
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM
Other Designations
OTTHUMP00000018592|OTTHUMP00000018593|STE20-like kinase 3|serine/threonine kinase 24|sterile 20-like kinase 3
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Interactome
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Disease
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Publication Reference
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Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.
Huang CY, Wu YM, Hsu CY, Lee WS, Lai MD, Lu TJ, Huang CL, Leu TH, Shih HM, Fang HI, Robinson DR, Kung HJ, Yuan CJ.
The Journal of Biological Chemistry 2002 Jul; 277(37):34367.
Application:WB, Human, Jurkat cells.
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An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.
Christian SL, McDonough J, Liu Cy CY, Shaikh S, Vlamakis V, Badner JA, Chakravarti A, Gershon ES.
Genomics 2002 May; 79(5):635.
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Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.
Zhou TH, Ling K, Guo J, Zhou H, Wu YL, Jing Q, Ma L, Pei G.
The Journal of Biological Chemistry 2000 Jan; 275(4):2513.
Application:WB-Ti, WB-Tr, Human, Rat, HEK 293 cells, Brain, Heart, Liver, Kidney, Spleen.
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Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.
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