MAP3K10 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The MAP3K10 polyclonal antibody (Cat # PAB2293) is used in Western blot to detect MAP3K10 in transfected COS-7 cell lysate. Data is kindly provided by Drs. M.K. Barthwal and A. Rana from Texas A&M University, Health Science Center (Temple, TX) .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the MAP3K10 polyclonal antibody (Cat # PAB2293) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP3K10.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MAP3K10.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The MAP3K10 polyclonal antibody (Cat # PAB2293) is used in Western blot to detect MAP3K10 in transfected COS-7 cell lysate. Data is kindly provided by Drs. M.K. Barthwal and A. Rana from Texas A&M University, Health Science Center (Temple, TX) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the MAP3K10 polyclonal antibody (Cat # PAB2293) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — MAP3K10
Entrez GeneID
4294Protein Accession#
Q02779Gene Name
MAP3K10
Gene Alias
MLK2, MST
Gene Description
mitogen-activated protein kinase kinase kinase 10
Omim ID
600137Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq
Other Designations
MKN28 derived nonreceptor_type serine/threonine kinase|MKN28 kinase|mixed lineage kinase 2
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Interactome
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Pathway
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Publication Reference
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Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.
Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ.
European Journal of Biochemistry 1995 Dec; 234(2):492.
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Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain.
Katoh M, Hirai M, Sugimura T, Terada M.
Oncogene 1995 Apr; 10(7):1447.
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Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.
Dorow DS, Devereux L, Dietzsch E, De Kretser T.
European Journal of Biochemistry 1993 Apr; 213(2):701.
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Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.
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