MAP3K7IP3 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon with MAP3K7IP3 polyclonal antibody (Cat # PAB22722) shows strong cytoplasmic positivity in goblet cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant MAP3K7IP3.
Immunogen
Recombinant protein corresponding to amino acids of human MAP3K7IP3.
Sequence
QPKPPFSVNPVYITYTQPTGPSCTPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYA
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human colon with MAP3K7IP3 polyclonal antibody (Cat # PAB22722) shows strong cytoplasmic positivity in goblet cells. -
Gene Info — MAP3K7IP3
Entrez GeneID
257397Protein Accession#
Q8N5C8Gene Name
MAP3K7IP3
Gene Alias
MGC45404, NAP1, TAB3
Gene Description
mitogen-activated protein kinase kinase kinase 7 interacting protein 3
Omim ID
300480Gene Ontology
HyperlinkGene Summary
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq
Other Designations
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3|NF-kappa-B-activating protein 1|NFkB activating protein 1|OTTHUMP00000023112|TAK1 binding protein 3|TAK1-binding protein 3
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Interactome
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