MAP3K1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP3K1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MAP3K1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MAP3K1 polyclonal antibody (Cat # PAB2272) in HL-60 cell lysate. MAP3K1 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry
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Gene Info — MAP3K1
Entrez GeneID
4214Protein Accession#
Q13233Gene Name
MAP3K1
Gene Alias
MAPKKK1, MEKK, MEKK1
Gene Description
mitogen-activated protein kinase kinase kinase 1
Omim ID
600982Gene Ontology
HyperlinkGene Summary
MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.[supplied by OMIM
Other Designations
MAP/ERK kinase kinase 1|MAPK/ERK kinase kinase 1|MEK kinase 1|OTTHUMP00000065818
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Interactome
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Pathway
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Publication Reference
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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
Xia Y, Wu Z, Su B, Murray B, Karin M.
Genes & Development 1998 Nov; 12(21):3369.
Application:WB-Tr, Monkey, COS-1 cells.
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Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5.
Vinik BS, Kay ES, Fiedorek FT Jr.
Mammalian Genome 1995 Nov; 6(11):782.
Application:WB-Ce, WB-Tr, Human, Mammalian cells.
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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
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